• Users Online: 530
  • Print this page
  • Email this page
 
REVIEW ARTICLE
Ahead of Print

SARS-CoV-2 viral load: Implication in COVID-19 pathogenesis, clinical presentation, diagnosis, treatment, prognosis and infectivity


 Department of Internal Medicine, (Division of Infectious Disease), All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India

Correspondence Address:
Prasan Kumar Panda,
Department of Internal Medicine, Division of Infectious Disease, All India Institute of Medical Sciences, Rishikesh, Uttarakhan
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/JME.JME_134_20

The SARS-CoV-2 viral load may have importance in assessing COVID-19's pathogenesis, clinical presentation, diagnosis, treatment, prognosis and infectivity. The severity of the disease has been attributed to the dysregulated immune mechanisms, but studies have suggested a correlation between disease severity and viral loads although evidence is not strong enough in justifying the same. Viraemia is shown to be keenly related to the disease progression. Viraemia has an association with increased Interleukin-6 levels and poorer prognosis. In terms of symptomatology, any definite correlations are not yet deduced, with no difference in viral loads among symptomatic and asymptomatic individuals. Reduction of viral load may be used as a marker of treatment success. Cycle threshold (Ct) values correlate with the SARS-CoV-2 viral loads. Ct values have shown a correlation with viral cultures and sub-genomic RNA values, both of which are considered the gold standard for determining infectivity but are expensive. Thereby, Ct value titres form an economical basis for deciding the de-isolation of the patients, which has implications in better resource management. Various limitations of viral load testing, especially of Ct values including human and laboratory factors are also discussed.


Print this article
Search
 Back
 
  Search Pubmed for
 
    -  Kapoor M
    -  Panda PK
 Citation Manager
 Article Access Statistics
 Reader Comments
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed344    
    PDF Downloaded11    

Recommend this journal